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KMID : 1177720140080010029
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Journal of Alternatives to Animal Experiments
2014 Volume.8 No. 1 p.29 ~ p.36
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Reconstructed Human Skin and Cornea Models as Alternative Methods to Animal Tests
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Lee Ne-Kyung
Park Hyeon-Ji
Lim Kyung-Min
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Abstract
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Cosmetics and drug products must be safe and effective to human and for ensuring their safety and efficacy, animal tests have been widely employed that ensued the sacrifice of numerous experimental animals. However, animal tests impose considerable pains and discomforts to laboratory animals and the results obtained cannot always predict the responses of human accurately. To resolve these ethical issues accompanying animal tests and to obtain more human-relevant test results, reconstructed human tissue models are being actively investigated and employed to animal alternative test methods. Especially, reconstructed human skin and cornea models have advanced into practical application steps in the development of cosmetics. Human reconstructed skin and cornea models provide high degrees of similarity to real human tissues and accordingly, they are expected to be able to produce more human relevant results. Their application to safety and efficacy tests of cosmetics have been continuously expanding. Here we review the current trends in the research of human reconstructed skin and cornea models.
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KEYWORD
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Cosmetics, 3D reconstructed tissue model, Safety, Efficacy
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